The School of Nursing is located in the Cohen Center on the Xavier campus. The building houses several academic departments, classrooms, lounge areas, and a Computer Lab. The School of Nursing has a Learning Resource Center furnished with materials needed to teach and practice nursing skills. Xavier's new state-of-the-art clinical simulation laboratoratories supplement the nursing student's clinical experiences by providing a futuristic simulated learning environment. Using human patient simulators, students have the opportunity to participate in Simulated Study challenging, real-life scenarios. Xavier's life-sized, computer driven human simulation mannequins blink, speak and breathe, as well as mirror accurate human reactions to procedures such as CPR, ventilation, catheterization and intubation.

The McDonald Library provides access to a large collection of hard copy and online nursing journals and books.