Freshmen Miranda Green and Suntana Granderson also dominated the game, both scoring career highs of 13 and 12 points respectively for Xavier.
The first half of the game was a heated match with 12 lead changes and six ties. The Wildcats, currently 4-3 for the season, got off to an early 8-4 advantage, but the Musketeers countered with five unanswered points.
Kentucky then went up 22-19 with a little more than six minutes left to play in the first half. Again a 5-0 run allowed Xavier to regain the lead, taking its biggest lead of the half with 30-26 on the scoreboard and just 1:45 remaining on the clock. The Musketeers held at 33-30 at the break.
Green scored seven of Xaviers first nine points of the second half while the Musketeers used a 15-0 run in the first seven minutes of the second half to open up a 48-30 lead. Kentucky didnt cut the deficit to single digits in the remainder of the game.
Boothes double-double is the second of the year and the 12th of her career. The graduate of Highlands High School in Fort Thomas, Ky., was 11-for-17 from the field, and she hit both her three-point attempts.
Green scored 11 of her points at the foul line as Xavier went 20-for-28 at the charity stripe.
The Musketeers shot 52.1 percent (25-48) for the game. The Wildcats hit just 29.2 percent (19-65) overall, with a low 21.9 percent (7-32) in the second half. UK was 1-for-16 in the three-point range for the game.
Jenny Pfeiffer led the Wildcats with 21 points.
Xavier, 5-2, is taking a week off for final exams before hosting Lipscomb University on Thursday, Dec. 18, at the Cintas Center.
The mens team, 4-2, plays its next game at undefeated Mississippi State University, 6-0, on Saturday, Dec. 13. The 8:00 p.m. tipoff is being broadcast on Fox Sports Net.